Sangam: A Confluence of Knowledge Streams

Experimental determination of the oral bioavailability and bioaccessibility of lead particles

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dc.contributor Civil and Environmental Engineering
dc.creator Deshommes, Elise
dc.creator Tardif, Robert
dc.creator Edwards, Marc A.
dc.creator Sauvé, Sébastien
dc.creator Prévost, Michèle
dc.date 2013-01-17T16:04:58Z
dc.date 2013-01-17T16:04:58Z
dc.date 2012-11-22
dc.date 2013-01-17T16:04:59Z
dc.date.accessioned 2023-03-01T18:53:25Z
dc.date.available 2023-03-01T18:53:25Z
dc.identifier Chemistry Central Journal. 2012 Nov 22;6(1):138
dc.identifier http://hdl.handle.net/10919/19162
dc.identifier https://doi.org/10.1186/1752-153X-6-138
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/281723
dc.description In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.
dc.description Published version
dc.format application/pdf
dc.format text/xml
dc.format application/pdf
dc.language en_US
dc.rights Creative Commons Attribution 4.0 International
dc.rights http://creativecommons.org/licenses/by/4.0/
dc.rights Elise Deshommes et al.; licensee BioMed Central Ltd.
dc.title Experimental determination of the oral bioavailability and bioaccessibility of lead particles
dc.title Chemistry Central Journal
dc.type Article - Refereed
dc.type Text


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