A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.National Institutes of Health (U.S.) (Grant GM 58160)National Institutes of Health (U.S.) (Postdoctoral Fellowship F32GM097771)National Science Foundation (U.S.) (CHE-9808061)