| dc.contributor |
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
|
| dc.contributor |
Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
|
| dc.contributor |
Massachusetts Institute of Technology. Institute for Data, Systems, and Society |
|
| dc.contributor |
Harvard University--MIT Division of Health Sciences and Technology |
|
| dc.creator |
Brown, Emery Neal |
|
| dc.date |
2021-04-27T15:56:32Z |
|
| dc.date |
2021-04-27T15:56:32Z |
|
| dc.date |
2019-10 |
|
| dc.date |
2021-04-06T18:27:47Z |
|
| dc.date.accessioned |
2023-03-01T18:06:50Z |
|
| dc.date.available |
2023-03-01T18:06:50Z |
|
| dc.identifier |
1021-5697 |
|
| dc.identifier |
https://hdl.handle.net/1721.1/130528 |
|
| dc.identifier |
Koch, Susanne et al. “Cognitive Impairment Is Associated with Absolute Intraoperative Frontal α-Band Power but Not with Baseline α-Band Power: A Pilot Study.” Dementia and Geriatric Cognitive Disorders, 48, 1-2 (October 2019): 83-92 © 2019 The Author(s) |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/278798 |
|
| dc.description |
Background: Cognitive abilities decline with aging, leading to a higher risk for the development of postoperative delirium or postoperative neurocognitive disorders after general anesthesia. Since frontal α-band power is known to be highly correlated with cognitive function in general, we hypothesized that preoperative cognitive impairment is associated with lower baseline and intraoperative frontal α-band power in older adults. Methods: Patients aged ≥65 years undergoing elective surgery were included in this prospective observational study. Cognitive function was assessed on the day before surgery using six age-sensitive cognitive tests. Scores on those tests were entered into a principal component analysis to calculate a composite "g score" of global cognitive ability. Patient groups were dichotomized into a lower cognitive group (LC) reaching the lower 1/3 of "g scores" and a normal cognitive group (NC) consisting of the upper 2/3 of "g scores." Continuous pre- and intraoperative frontal electroencephalograms (EEGs) were recorded. EEG spectra were analyzed at baseline, before start of anesthesia medication, and during a stable intraoperative period. Significant differences in band power between the NC and LC groups were computed by using a frequency domain (δ0.5-3 Hz, θ 4-7 Hz, α 8-12 Hz, β 13-30 Hz)-based bootstrapping algorithm. Results: Of 38 included patients (mean age 72 years), 24 patients were in the NC group, and 14 patients had lower cognitive abilities (LC). Intraoperative α-band power was significantly reduced in the LC group compared to the NC group (NC -1.6 [-4.48/1.17] dB vs. LC -6.0 [-9.02/-2.64] dB), and intraoperative α-band power was positively correlated with "g score" (Spearman correlation: r = 0.381; p = 0.018). Baseline EEG power did not show any associations with "g." Conclusions: Preoperative cognitive impairment in older adults is associated with intraoperative absolute frontal α-band power, but not baseline α-band power. |
|
| dc.description |
Seventh Framework Programme (European Commission) (FP7/2007-2013) (Grant HEALTH-F2-2014-60246) |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
S. Karger AG |
|
| dc.relation |
10.1159/000502950 |
|
| dc.relation |
Dementia and Geriatric Cognitive Disorders |
|
| dc.rights |
Creative Commons Attribution-Noncommercial-Share Alike |
|
| dc.rights |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
|
| dc.source |
PMC |
|
| dc.title |
Cognitive Impairment Is Associated with Absolute Intraoperative Frontal α-Band Power but Not with Baseline α-Band Power: A Pilot Study |
|
| dc.type |
Article |
|
| dc.type |
http://purl.org/eprint/type/JournalArticle |
|