| dc.contributor |
Massachusetts Institute of Technology. Department of Biology |
|
| dc.contributor |
Boulias, Konstantinos |
|
| dc.contributor |
Horvitz, H. Robert |
|
| dc.creator |
Boulias, Konstantinos |
|
| dc.creator |
Horvitz, Howard Robert |
|
| dc.date |
2014-11-26T20:07:28Z |
|
| dc.date |
2014-11-26T20:07:28Z |
|
| dc.date |
2012-04 |
|
| dc.date |
2012-02 |
|
| dc.date.accessioned |
2023-03-01T18:05:00Z |
|
| dc.date.available |
2023-03-01T18:05:00Z |
|
| dc.identifier |
15504131 |
|
| dc.identifier |
http://hdl.handle.net/1721.1/91945 |
|
| dc.identifier |
Boulias, Konstantinos, and H. Robert Horvitz. “The C. Elegans MicroRNA Mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO.” Cell Metabolism 15, no. 4 (April 2012): 439–450. © 2012 Elsevier Inc. |
|
| dc.identifier |
https://orcid.org/0000-0002-9964-9613 |
|
| dc.identifier |
https://orcid.org/0000-0002-5117-3994 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/278680 |
|
| dc.description |
The life span of Caenorhabditis elegans is controlled by signaling between the germline and the soma. Germ cell removal extends life span by triggering the activation of the DAF-16/FOXO transcription factor in the intestine. Here we analyze microRNA function in C. elegans aging and show that the microRNA mir-71 functions to mediate the effects of germ cell loss on life span. mir-71 is required for the life span extension caused by germline removal, and overexpression of mir-71 further extends the life span of animals lacking germ cells. mir-71 functions in the nervous system to facilitate the localization and transcriptional activity of DAF-16 in the intestine. Our findings reveal a microRNA-dependent mechanism of life span regulation by the germline and indicate that signaling among the gonad, the nervous system, and the intestine coordinates the life span of the entire organism. |
|
| dc.description |
Howard Hughes Medical Institute |
|
| dc.description |
European Molecular Biology Organization (Fellowship) |
|
| dc.description |
Ellison Medical Foundation (Grant) |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.publisher |
Elsevier |
|
| dc.relation |
http://dx.doi.org/10.1016/j.cmet.2012.02.014 |
|
| dc.relation |
Cell Metabolism |
|
| dc.rights |
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. |
|
| dc.source |
Elsevier |
|
| dc.title |
The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO |
|
| dc.type |
Article |
|
| dc.type |
http://purl.org/eprint/type/JournalArticle |
|